ETG 4000

High-quality, real-time cerebral-cortex-imaging and measurement

Every healthcare professional would say: "I wish I could see how the human brain is working in vivo." Hitachi’s highly portable, bedside optical topography system has made this dream come true and enables professionals to inspect and measure live, in-vivo images of the human brain, while it is working. It captures and measures haemoglobin levels, while the brain functions. This system is non-invasive and requires little or no patient restraint.

The state-of-the-art optical topography system transmits near-infrared light into the patient’s head and collects the reflected information from the cerebral cortex. Hitachi has opened up a well-needed new way of assessing the brain.

  • Compact, mobile and user-friendly
    A highly portable, compact and light unit which is easy to wheel up to the bedside or around a clinic. It has an extremely user friendly and efficient on-screen interface and rapidly generates accurate test results.
  • Simultaneous multi-channel measurement
    A wide range of probes and holders enable a variety of assessments. This system can be configured to simultaneously take 24, 48 or 52 channel measurements.
  • Live, non-invasive measurement with little or no patient restraint.
    Just place the sensor on the scalp while the optical topographer captures and measures real time images of live brain activity.
  • Measurement channels:
    Available in 24 and 48 channel configurations. 52 channels can be measured with an optional 3x11 probe.
  • Measurements:
    Changes in oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin concentrations.
  • Light source:
    Laser diodes of two wavelengths (695nm and 830 nm) measure oxy- and deoxy-hemoglobin simultaneously. The shorter wavelength light source enables multi-faced measurements with very low levels of background noise.
  • Display format:
    Time-course graph display, 2D topographic images and mapped displays.
  • Data sampling rate:
    10 samples per second.
  • Interface:
    RS232 and BNC for external trigger and signal input/output.
  • Network:
    LAN compatible for data sharing.
  • Data format:
    Measurement data can be generated in text or Excel compatible files. Topographic images are available in BMP or AVI formats.

The ETG-4000 was engineered for ease of use in clinical and research environments. Possible fields of application include neuroscience, psychology, psychiatry, neonatology and education.

  • Motor tasks.
  • Speech recognition studies.
  • Visual stimulation.
  • Psychiatric disorders including depression and schizophrenia.
  • Effects of aging (dementia) – development of preventive diagnostics.
  • Neonatal – early detection of difficulties including audio sense, speech and visual.
  • Pediatric – learning difficulties including ADHD and mental retardation.
  • Language lateralization – assessment of hemispheric dominance for language before surgery (alternative to Wada test).
  • Seizures – detection before surgery (epilepsy).
  • Stroke assessment and rehabilitation

The research in functional near-infrared spectroscopy (fNIRS) is growing worldwide. Here are some recently published papers by European users of Hitachi Optical Topography systems.

The neonate brain detects speech structure

Keywords: language acquisition, newborns, optical imaging, perceptual primitives, speech perception

Gervain, Macagno, Cogol, Peno, Mehler

International School for Advanced Studies, Trieste, Italy

PNAS, Sep 16, 2008, Vol. 105, No 37

Activation of the Prefrontal Cortex in Working Memory and Interference Resolution Processes Assessed with NIRS

Keywords: prefrontal cortex, event-related, working memory, attention, interference resolution

Schreppel, Egetemeir, Schecklmann, Plichta, Pauli, Ellgring, Fallgatter, Herrmann

University of Wuerzburg

Neuropsychobiology 2008; 57:188-193

Diminished prefrontal oxygenation with normal and above-average verbal fluency performance in adult ADHD

Keywords: brain oxygenation, hyperfocus, verbal fluencey, ADHD

Schecklmann, Ehlis, Plichta, Romanos, Heine, Boreatti-Hümmer, Jacob, Fallgatter

University of Wuerzburg

Journal of Psychiatric Research 43 (2009) 98-106

Differential activation of frontal and parietal regions during visual word recognition: an OT study

Keywords: lexical decision, word frequency, lexicality, probabilistic mapping

Hofmann, Herrmann, Dan, Obrig, Conrad, Kuchinke, Jacobs, Fallgatter

Charité Berlin; University of Wuerzburg

Neuroimage 40 (2008) 1340-1349

Spatio-temporal differences in brain oxygenation between movement execution and imagery: A multi-channel NIRS study

Keywords: motor execution, motor imagery

Wriessnegger, Kurzmann, Neuper

University Graz

International Journal of Psychophysiology 67 (2008) 54-63

Functional optical signal analysis: a software tool for NIRS data processing incorporating statistical parametric mapping

Keywords: biomedical optics, data processing

Koh, Glaser, Flandin, Kiebel, Butterworth, Maki, Delpy, Elwell

University College London

Journal of Biomedical Optics 12(6), 064010 (November/December 2007)

Event-Related Functional Near-Infrared Spectroscopy (fNIRS) Based on Craniocerebral Correlations: Reproducibility of Activation?

Keywords: retest reliability, reproducibility, event related, motor task

Plichta, Herrmann, Baehne, Ehlis, Richter, Pauli, Fallgatter

University of Wuerzburg

Human Brain Mapping 28:733-741 (2007)

Model-based analysis of rapid event-related functional near-infrared spectroscopy data: a parametric validation study

Keywords: time-series-analysis, GLM, Two-stage ordinary lease square, OLS, parametric design

Plichta, Heinzel, Ehlis, Pauli, Fallgatter

University of Wuerzburg

NeuroImage 35 (2007) 625-634

Cerebral oxygenation changes in the prefrontal cortex: Effects of age and gender

Keywords: sex, aging, verbal fluency task

Herrmann, Walter, Ehlis, Fallgatter

University of Wuerzburg

Neurobiology of Aging 27 (2006) 888-894

Multi-channel near-infrared spectroscopy detects specific inferior-frontal activation during incongruent Stroop trials

Keywords: Stroop task, cognitive interference

Ehlis, Herrmann, Wagener, Fallgatter

University of Wuerzburg

Biological Psychology 69 (2005) 315-331

Towards a standard analysis for functional near infrared imaging

Keywords: general liner model, spectral analysis, visual stimulation

Schroeter, Bücheler, Müller, Uludag, Obrig, Lohmann, Tittgemeyer, Villringer, v.Cramon

Max-Planck Institute, Leipzig

Neuroimage 21 (2004) 283-290

Sounds and Silence: An optical topography study of language recognition at birth

Keywords: left hemisphere dominance, neonates, forward speech, backward speech

Pena, Maki, Kovacic, Dehaene-Lambertz, Koizumi, Bouquet, Mehler

International School for Advanced Studies, Trieste

PNAS 2003, vol.100, no.20 11702-11705